A placebo-controlled double-blind assessment. : CD008016. Antipsychotic drugs are the mainstay of treatment of schizophrenia, not only in the event of acute episodes, but also in the long-term perspective. The study involved more than 62,000 Finns who had received a schizophrenia diagnosis at some point between 1972 and 2014. The trials were published from 1959 to 2017 and their size ranged between 14 and 420 participants. https://doi.org/10.1001/jamapsychiatry.2017.0624, Helfer B, Samara MT, Huhn M et al (2016) Efficacy and safety of antidepressants added to antipsychotics for schizophrenia: a systematic review and meta-analysis. Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol. Int J Neuropsychopharmcol 13:215. https://doi.org/10.1017/S1461145710000635, Kirkpatrick B, Fenton WS, Carpenter WT et al (2006) The NIMH-MATRICS consensus statement on negative symptoms. Article Neuropsychopharmacology 33(10):2303–2312. Cariprazine was better than risperidone in a large trial that was well-controlled for secondary negative symptoms, but the trial was sponsored by its manufacturer. PubMed Psych Central does not provide medical or psychological https://doi.org/10.1176/ajp.145.5.578, Article For people with schizophrenia, the evidence suggests that maintenance on antipsychotic drugs prevents relapse to a much greater extent than placebo for approximately up to two years of follow-up. We included 21 randomized-controlled trials with 3451 participants which revealed the following significant differences in the primary outcome: in patients with predominant negative symptoms amisulpride was superior to placebo (N = 4; n = 590, SMD 0.47, CI 0.23, 0.71), olanzapine was superior to haloperidol in a small trial (n = 35) and cariprazine outperformed risperidone (N = 1, n = 456, SMD − 0.29, CI − 0.48, − 0.11). Special thanks to Rolf Engel, who participated in the development of the project and supervised Marc Krause for his doctoral thesis of which this publication will be part. Doctors will choose which medication is best by looking at the following: There are two groups of antipsychotics. https://doi.org/10.1124/jpet.109.160432, Jensen NH, Rodriguiz RM, Caron MG et al (2008) N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine’s antidepressant activity. PubMed Google Scholar. Mol Psychiatry 14(4):429–447. https://doi.org/10.1002/wps.20385, Article For people with schizophrenia, the evidence suggests that maintenance on antipsychotic drugs prevents relapse to a much greater extent than placebo for approximately up to two years of follow-up. PubMed Central Stefan Leucht. A meta-analysis. Google Scholar, Kinon BJ, Noordsy DL, Liu-Seifert H et al (2006) Randomized, double-blind 6-month comparison of olanzapine and quetiapine in patients with schizophrenia or schizoaffective disorder with prominent negative symptoms and poor functioning. For continuous data, we calculated mean differences (MD) or standardised mean differences (SMD), again based on a random-effects model. First- and Second-Generation Antipsychotics for Children and Young Adults, Agency for Healthcare Research and Quality, 2012. Google Scholar, White IR, Barrett JK, Jackson D et al (2012) Consistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regression. Learn more about Institutional subscriptions, Buchanan RW, Kirkpatrick B, Heinrichs DW et al (1990) Clinical correlates of the deficit syndrome of schizophrenia. (2006) Improving the quality of randomized controlled trials in Chinese herbal medicine, part I: clinical trial design and methodology. The results of this review show very consistently that antipsychotic drugs effectively reduce relapses and need for hospitalisation. Neuropsychobiology 39(1):25–32, Kiss B, Horváth A, Némethy Z et al (2010) Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. Schizophr Res 186:19–28. 1998 Apr;9(4):325-40. doi: 10.2165/00023210-199809040-00007. https://doi.org/10.1002/jrsm.1044, Article The … eCollection 2014 Jun. Diverse definitions of the early course of schizophrenia-a targeted literature review. 2005 Oct;162(10):1785-804 volume 268, pages625–639(2018)Cite this article. JAMA Psychiatry 74(7):675–684. Antipsychotic drugs were more effective than placebo in preventing relapse at seven to 12 months (primary outcome; drug 24% versus placebo 61%, 30 RCTs, n = 4249, RR 0.38, 95% CI 0.32 to 0.45, number needed to treat for an additional beneficial outcome (NNTB) 3, 95% CI 2 to 3; high-certainty evidence).
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